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  • 產品名稱:Mambalgin-1

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  • 產品廠商:Smartox-Biotech
  • 產品價格:444.68
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簡單介紹:
Mambalgin-1
詳情介紹:
Sequence AA sequence: Leu-Lys-Cys3-Tyr-Gln-His-Gly-Lys-Val- Val-Thr-Cys12-His-Arg-Asp-Met-Lys-Phe-Cys19-Tyr- His-Asn-Thr-Gly-Met-Pro-Phe-Arg-Asn-Leu- Lys-Leu-Ile-Leu-Gln-Gly-Cys37-Ser-Ser-Ser -Cys41-Ser-Glu-Thr-Glu-Asn-Asn-Lys-Cys49 -Cys50-Ser-Thr-Asp-Arg-Cys55-Asn-Lys -OH Disulfide bonds: Cys3-Cys19, Cys12-Cys37, Cys41-Cys49, Cys50-Cys55
Characteristics ASIC1a & 1b channel blocker
Background Mambalgin-1 was initially isolated by Sylvie Diochot and collaborators from the venom of the black mamba (Dendroaspis polylepis polylepis). Mambalgin-1 is a potent and selective blocker of acid-sensing ion channels (ASIC). ASIC channels have been demonstrated to be implied in pain pathways and appear to be promising therapeutic targets. Mambalgin-1 rapidly and reversibly inhibits recombinant homomeric ASIC1a (IC50=55 nM) and heteromeric ASIC1a+ASIC2a (IC50=246 nM) or ASIC1a+ASIC2b channels (IC50=61 nM) but also human channels hASIC1b (IC50=192 nM) and hASIC1a+hASIC1b (IC50=72nM). Mambalgin-1 belongs to the family of three-finger toxins and has no sequence/structural homology with either PcTx1 or APETx2. Mambalgin-1 differs from mambalgin-2 by one amino acid. Both have demonstrated a similar activity. Mambalgin-1 has no effect on ASIC2a, ASIC3, ASIC1a+ASIC3 and ASIC1b+ASIC3 channels, as well as on TRPV1, P2X2, 5-HT3A, Nav1.8, Cav3.2 and Kv1.2 channels.
Molecular Weight 6554.59 kDa
Restrictions For Research Use only
Storage -20 °C
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